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Lamictal (Lamotrigine)

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Lamictal or lamictal generic is an anticonvulsant.
Pharmacological action.
Antiepileptic drug. Lamotrigine or lamictal generic is a blocker of voltage-dependent sodium channels. In the culture of neurons it causes voltage-dependent blockade of continuously repeating impulses and inhibits pathological release of glutamate (an amino acid that plays a key role in the development of epileptic seizures), as well as inhibit the depolarization induced by glutamate.
The effectiveness of lamictal (Lamotrigine) in preventing mood disorders for patients with bipolar disorder was demonstrated in two fundamental clinical research. In the combined analysis of the results showed that the duration of remission, defined as the time to first depressive episode and before the first episode of mania / hypomania / mixed after stabilization, longer in the lamotrigine( lamictal generic )compared with placebo. Duration of response was more pronounced for depression.

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Pharmacokinetics.
After oral administration lamictal is rapidly and completely absorbed from the gastrointestinal tract, practically without undergoing first-pass metabolism. C max in plasma is reached approximately 2.5 h after dosing.
Lamotrigine or lamictal generic binds to plasma proteins, approximately on 55%.
The half-life in healthy adults is on average of 24 h to 35 h.
For children, the half-life of lamotrigine is usually smaller than for adults. Its average value is approximately 7 hours.

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Indications for use.
Seizures in adults (monotherapy and combination therapy) and children older than 2 years (only in part of combined therapy by antiepileptic drugs): partial and generalized seizures. Bipolar disorder (manic depression).
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Dosage.
Monotherapy: Adults and children older than 12 years: an initial dose is lamictal 25 mg 1 time a day for 2 weeks, then increased to lamictal 50 mg 1 time per day for 2 weeks. In order to achieve optimal therapeutic effect increase the dose of lamictal 50-100 mg every 1-2 weeks. Maintenance dose - 100-200 mg / day in 1-2 doses. In some cases, to achieve a therapeutic effect required dose of 500 mg / day.
During therapy lamictal or lamictal generic with valproic acid in combination with other antiepileptic drugs or without it: an initial dose - 25 mg every other day for 2 weeks, then - 25 mg 1 time a day for 2 weeks. In order to achieve optimal therapeutic effect increase the dose of 25-50 mg every 1-2 weeks. Maintenance dose - 100-200 mg / day in 1-2 doses.
During therapy with antiepileptic drugs which induce "liver" enzymes (phenytoin, carbamazepine, phenobarbital and primidone), in combination with other antiepileptic drugs with or without them (except valproic acid): initial dose - 50 mg 1 time a day for 2 weeks, then - 100 mg / day in 2 divided doses for 2 weeks. In order to achieve optimal therapeutic effect increase the dose to a maximum of 100 mg every 1-2 weeks.
Maintenance dose - 200-400 mg / day for 2 hours. For some patients to achieve a therapeutic effect may be required dose 700 mg / day. Children from 2 to 12 years: the first 2 weeks - 2 mg / kg / day in 2 divided doses, then 2 weeks - 5 mg / kg / day, then increased to 2-3 mg / kg every 1-2 weeks prior to onset of effect (typically 5-15 mg / kg / day in 2 divided doses, maximum 400 mg / day). Children aged 2 to 12 years to achieve the optimal therapeutic effect shall adjust the dosage according to changes in body weight.
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Until you order lamictal online, look contraindications.
Contraindications.
Hypersensitivity. Pregnancy, lactation.

Side effects of lamictal.
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The nervous system: headache, fatigue, dizziness, drowsiness or insomnia, irritability, aggression, tremor, anxiety, confusion. From the senses: diplopia, blurred vision, conjunctivitis, impaired balance. On the part of hematopoiesis: leukopenia, and thrombocytopenia. Part of the digestive system: nausea, vomiting. Allergic reactions: skin rash maculopapular more (usually within the first 8 weeks of treatment, going after drug withdrawal), hypersensitivity syndrome.

Overdose.
Symptoms: nystagmus, ataxia, dizziness, headache, drowsiness, vomiting, impaired consciousness, coma. Treatment: hospitalization, gastric lavage, activated charcoal, symptomatic therapy.

Product forms.
Pills lamictal 100 mg,
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lamictal 25 mg.

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